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Onyx Pharmaceuticals

About Onyx Inc

Onyx Pharmaceuticals is developing innovative small molecule cancer treatments based on a molecular understanding of cancer.

Onyx's lead product candidate is BAY 43-9006, a novel, orally active signal transduction inhibitor. that inhibits both tumor cell proliferation and angiogenesis (the formation of new blood vessels to support cancer cell growth).

BAY 43-9006 is the first compound to target both the RAF/MEK/ERK (MAPK) signaling pathway to inhibit cell proliferation and the VEGFR-2/PDGFR- signaling cascade to inhibit tumor angiogenesis.

The MAPK pathway represents a cascade of phosphorylation events including three pivotal kinases, namely Raf, MEK (MAP kinase kinase), and ERK (MAP kinase). These kinases present new opportunities for the development of novel anti-cancer drugs designed to be target-specific and probably less toxic than conventional chemotherapeutic agents.






Onyx's lead product, BAY 43-9006, is an orally active, small molecule agent in clinical trial for patients with advanced renal (kidney) cancer. In addition, the agent is being studied in Phase II trials in melanoma, breast, lung and other cancers, as well as in several Phase Ib trials of the agent administered in conjunction with standard chemotherapy drugs. BAY 43-9006 was discovered and is being codeveloped by Onyx and Bayer Pharmaceuticals Corporation.





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