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Nuvelo Inc.

About Nuvelo Inc

Nuvelo, Inc. is a publicly traded biopharmaceutical company dedicated to the discovery, development and commercialization of life improving therapeutics for the treatment of acute cardiovascular indications and cancer.

Nuvelo’s clinical pipeline includes three product candidates:

1. alfimeprase, a direct acting thrombolytic for the treatment of acute peripheral arterial occlusion (PAO) and catheter occlusion;

2. rNAPc2, an anticoagulant that inhibits factor VIIa/tissue factor and

3. ARC183, a direct thrombin inhibitor that is being developed for use in acute anticoagulant applications.

In addition to its clinical development pipeline, Nuvelo expects to leverage its proprietary research programs and expertise in secreted proteins and antibody discovery to expand its pipeline and create partnering and licensing opportunities.



Alfimeprase -- A Novel Acting Thrombolytic -- Alfimeprase is an enzyme produced by recombinant DNA technology. It is a thrombolytic agent or blood clot dissolver that is intended to directly degrade fibrin when delivered through a catheter at the site of a blood clot.

rNAPc2 -- Factor VIIa / Tissue Factor Inhibitor --Recombinant nematode anticoagulant protein c2 (rNAPc2) is a recombinant version of a naturally occurring protein that has anticoagulant properties. The mechanism of action lies in its ability to block the factor VIIa/tissue factor protease complex, which is responsible for the initiation of blood clot formation

ARC183 -- Direct Thrombin Inhibitor --ARC183 is a DNA-based direct thrombin inhibitor that is currently being developed as an anticoagulant / anti-thrombotic. ARC183 is currently under investigation for its rapid onset of action and short half-life, potentially negating the need for an antidote to stop its anticoagulant effect. This gives ARC183 the potential to be further investigated for medical procedures such as coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention.



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