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Nuerocrine Biosciences

About Nuerocrine Biosciences

Neurocrine Biosciences, Inc. is a product-based biopharmaceutical company focused on neurological and endocrine-related diseases and disorders. Our product candidates address some of the largest pharmaceutical markets in the world including insomnia, anxiety, depression, various female and male health disorders, multiple sclerosis, diabetes, irritable bowel syndrome, eating disorders, pain, and autoimmunity disorders.

Neurocrine currently has 17 programs in various stages of research and development.

Six of these programs have been advanced into clinical trials.

Our lead clinical development program, indiplon, for the treatment of insomnia, partnered with Pfizer, has had two New Drug Applications filed with the Food and Drug Administration (FDA).

We have successfully completed three Phase I single and multiple dose trials with GnRH (Gonadotropin-releasing Hormone) for the treatment of women's health disorders.

The Company has two Altered Peptide Ligand (APL) products in Phase II clinical development, NBI-5788 for multiple sclerosis, and NBI-6024 for Type I Diabetes.

Neurocrine initiated a Phase I clinical trial with its proprietary compound, urocortin 2 in healthy volunteers to expects to initiate a Phase II clinical study in patients with mild to moderate congestive heart disease in early 2005.



Clinical Trial Data for Neurocrine Biosciences


Indiplon-- Insomnia -- -- action by enhancing the action of the inhibitory neurotransmitter GABA

CRF R Antagonist -- Anxiety and depression

NBL- 5788-- Multiple Sclerosis

Urocortin 2 -- Acute congestive heart failure (CHF)

GnRH Antagonist -- Endometriosis


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