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Ligand Pharmaceuticals

About Ligand

Ligand's business strategy has long been to build a profitable, high-growth pharmaceutical company based on two diversified product pipelines.

In LIGAND, their products ONTAK®, Targretin® capsules and Targretin gel are approved for cutaneous T-cell lymphoma, and Panretin® gel is approved for AIDS-related Kaposi's sarcoma. Their fifth product, AVINZA®, is approved for chronic, moderate-to-severe pain and was launched in the second quarter of 2002.

Ligands most important clinical development program is for Targretin capsules in non-small cell lung cancer. In addition,Clinical Trials are ongoing for ONTAK in B- and T-cell non-Hodgkin's lymphomas and chronic lymphocytic leukemia, and for Targretin gel in hand dermatitis.

In LCPP, Ligand has formed partnerships with 11 major pharmaceutical companies, including Pfizer, Wyeth, GlaxoSmithKline and Lilly. These partners have approximately 20 potential products in various stages of development, many for diseases with multibillion-dollar markets. Three of these products are second-generation selective estrogen receptor modulators (SERMs):

lasofoxifene, which Pfizer is developing for osteoporosis and other indications;

bazedoxifene --osteoporosis;

and bazedoxifene/PREMARIN®, which Wyeth is developing for osteoporosis and menopausal symptoms.



Pipeline for Ligand



Clinical Trials for ONTAK

Clinical Trials for Tagretin


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