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Entremed Inc

About Entremed

EntreMed is a clinical-stage pharmaceutical company focused on developing the next generation of multi-mechanism oncology and anti-inflammatory drugs which directly target disease cells and the blood vessels that nourish them.

Panzem® (2-methoxyestradiol or 2ME2),is the Company’s lead drug candidate, and is currently in clinical trials for cancer.

EntreMed compounds work through multiple mechanisms of action (MOA) e.g., 2ME2’s MOAs include the inhibition of 1) angiogenesis, 2) microtubule formation, 3) hypoxia inducible factor-1 alpha (HIF-1a) and 4) osteoclastic activity (bone resorption), as well as 5) the induction of apoptosis.

EntreMed’s goal is to develop and commercialize new compounds based on the Company’s expertise in the science of angiogenesis, cell cycle regulation and inflammation -- processes vital to the treatment of cancer and other diseases. Entremed has identified several new molecules, including analogs of 2ME2, modulators of fibroblast growth factor-2 (FGF-2) activity, tissue factor pathway inhibitor (TFPI) peptides, and proteinase activated receptor-2 (PAR-2) antagonists.


Pipeline for Entremed


Panzem Capsules



Preclinical Trials:

NCD 2ME2 (2-Methoxyestradiol)

--Analogs of 2ME2

---ENMD 0996 (FGF-2 Cancer Vaccine)

---Tissue Factor Pathway Inhibitors (TFPI)

---Proteinase Activated Receptor-2 (PAR-2) Inhibitors


Clinical Trials


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