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About Axonyx:

AXONYX is a biopharmaceutical company engaged in the business of acquiring and developing novel post-discovery central nervous system drug candidates, primarily in areas of memory and cognition.

Phenserine is Axonyx's lead compound in development for the treatment of Alzheimer's Disease (AD). Phenserine is a potent and selective inhibitor of acetylcholinesterase. Phenserine has been shown to increase memory and learning in the rat over a wide therapeutic range.

Phenserine works through two mechanisms:

(1) it inhibits the degradation of the neurotransmitter acetylcholine in the brains of animals, and

(2) it inhibits the production of a toxic form of the beta-amyloid protein in the brain that is thought to be a cause of the death of brain cells in AD.

Note: Phenserine failed phase III trial for mild to moderate Alzheimer's Disease.

The company has also acquired the patent rights to two additional platform technologies, the prion and amyloid inhibiting peptides (PIP's and AIP's respectively). The AIP's (beta-sheet breakers) have the potential to disrupt and/or breakup the toxic beta-amyloid plaque that surrounds the nerve cells of patients with AD. AXONYX received a $1 million milestone payment when Serono initiated a Phase I clinical trial with a beta-sheet breaker peptide for the potential treatment of AD.

AXONYX also has co-inventorship rights to a therapeutic compound named Posiphen designed for the treatment of AD and other cognitive disorders.

Pipeline info for Axonyx


Phase IIIPhenserineAlzheimers (failed on 2/07/05)
Phase II PhenserineAlzheimers
Phase IPhenserine Alzheimers


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