Drugs
at the Clinical Stage -- In the Pipeline The
Biotech-100 Index includes 100 small cap biotechnology stocks whose product drug
pipeline contain at least one drug in either phase II and/or Phase III clinical
development. There is a 90% chance of rejection in early-stage phase I clinical
trials; a 50% chance in phase II; 20% in phase III; and 10% post-phase III. Companies
that are in phase II and III tend to show great promise but still have a high
degree of volatiliy. Non-Hodgkin's Lymphoma
Pipeline Drugs Company Symbol
ABX-EGF
(panitumumab) Abgenix ABGX targets
the epidermal growth factor
receptor (EGFr), which is over-expressed in a variety of cancers including lung
cancer, breast cancer,
bladder, pancreatic,
colorectal cancer,
kidney and head and neck cancer. ABX-MA1 Abgenix ABGX ABX-MA1
targets a protein called MUC18, a cell-surface adhesion molecule that is highly
expressed on metastatic melanoma
cells but not on normal skin cells ACP-103 Acadia ACAD
Parkinson's
Disease, adjunctive therapy for schizophrenia
(Hallucinations, Psychoses) Onconase
(ranpirnase) AlfaCell ACEL Ribonuclease
anti-cancer drug,
Entereg
(alvimopan) Adolor
ADLR
pain
management of POI and OBD
lidocaine
patch Adolor
ADLR postoperative
incisional pain cetrorelix Æterna
Zentaris Inc AEZS oncology
and endocrine therapy perifosine Æterna
Zentaris Inc AEZS signal
transduction inhibitor (cancer) Teverelix,,
D63153 Æterna
Zentaris Inc AEZS prostate
cancer -BPH Lobaplatin Æterna
Zentaris Inc AEZS Small
cell lung cancer, breast,
chronic myelogenous leukemia
(CML) Neovastat Æterna
Zentaris Inc AEZS Non-small
cell lung cancer RC-3095 Æterna
Zentaris Inc AEZS Multiple
cancers AG-858 Antigenics
Inc. AGEN Chronic
myelogenous leukemia (CML)
Oncophage Antigenics
Inc. AGEN Metastatic
melanoma, Kidney cancer (renal cell carcinoma) AG-702 Antigenics
Inc. AGEN Genital
herpes V
-Protectants® (AGI-1067) Atherogenics AGIX chronic
inflammatory diseases, such as atherosclerosis,
rheumatoid arthritis and asthma
Vivitrex Alkermes ALKS Alchol
Dependence
Medisorb Alkermes ALKS Diabetes
AIR Insulin
Alkermes ALKS Diabetes
AIR hGH
Alkermes ALKS GHD
AIR Epinephrine
Alkermes ALKS Anaphylaxis Pexelizumab Alexion ALXN Cardiopulmonary
Bypass, Acute Myocardial Infarction Eculizumab Alexion ALXN Nephritis,
Dermatomyositis , Paroxysmal Nocturnal Hemoglinuria Efaproxiral
Allos
Therapeutics ALTH Brain
metastases from breast
cancer, non-small cell lung
cancer, cervical cancer
PDX
(pralatrexate) Allos
Therapeutics ALTH non-small
cell lung cancer, Mesothelioma,
non-Hodgkin's Lymphoma
SYMLIN®
(pramlintide acetate) Amylin AMLN synthetic
version of human amylin -glucose control with type 1 diabetes exenatide
(synthetic exendin-4) Amylin AMLN
type 2 diabetes Isatoribine
(ANA245) Anadys ANDS Hepatitis
C ANA
380 Anadys ANDS Hepatitis
B Oral
Prodrug ANA971 Anadys ANDS reduce
the risk of HCV relapse AMD3100 AnorMED AOM.TO stem
cell mobilizer
AMD070 AnorMED AOM.TO chemokine
inhibitor for HIV Insegia(G17DT
immunogen) Aphton
Corp APHT cancer
and gastrointestinal disease AP23573 Ariad ARIA
solid tumor and blood malignancies TP10
Avant AVAN Cardiac
Surgery CETi-I
Avant AVAN Cholesterol
Management CholeraGarde
Avant AVAN Cholera
Ty800 Avant AVAN Typhoid
Fever
Injectable
Anthrax Avant AVAN Anthrax
Therapore Avant AVAN HIV
Resten-NG
Avi
Biopharma AVII cardiovascular
restenosis
Avicine Avi
Biopharma AVII vaccine
-- anti-hCG immune response targeting hCG-producing cancer cells
NeuGene
compounds Avi
Biopharma AVII anti-sense
drugs for cancer, polycystic kidney disease, and viral diseases
Neurodex Avanir AVN pseudobulbar
affect, neuropathic pain
Avanir Avanir AVN Asthma AV201 Avigin AVGN severe
Parkinson's
disease Phenserine Axonyx AXYX Alzheimer's
disease
Theratope
Vaccine Biomira BIOM colorectal,
metastatic breast cancer
BLP25
Liposome Vaccine Biomira BIOM Prostate,
non-small cell lung cancer Modrenal Bioenvision
BIVN Prostate
Cancer Clofarabine
(CLOLAR) Bioenvision
BIVN pediatric
acute lymphoblastic leukemia, solid Tumors
Velostan Bioenvision
BIVN post-menopausal
advanced breast cancer,
bladder cancer virostat Bioenvision
BIVN hepatitis
C GVAX
(vaccine) Cell
Genesys CEGE Prostate,
lung, pancreatic, leukemia, myeloma
CG7870
Oncolytic Virus Therapy Cell
Genesys CEGE Prostate
cancer Daptomycin
(cubicin) Cubist CBST soft
tissue infection, infective endocarditis HepeX-B Cubist CBST prevention
of infection by hepatitis
B in liver transplant Oracea
Collagenex
Pharmaceuticals Inc CGPI rosacea
E2F
Decoy Corgentech CGTK Coronary
Bypass Graft, Arterio-Venous Graft mifepristone
( Corlux) Corcept CORT Psychotic
major depression, Alzheimers
XYOTAX Cell
Therapeutics CTIC non-small
cell lung cancer (NSCLC)
and ovarian cancer
Pixantrone Cell
Therapeutics CTIC non-Hodgkin's
lymphoma (NHL TRISENOX Cell
Therapeutics CTIC relapsed/refractory
acute promyelocytic leukemia CT-2106 Cell
Therapeutics CTIC anti-cancer
drug Ventavis CoTherix
Inc CTRX pulmonary
arterial hypertension
Ranexa CV
Therapeutics Inc CVTX Chronic
Angina Regadenoson CV
Therapeutics Inc CVTX Myocardial
Perfusion Imaging Tecadenoson CV
Therapeutics Inc CVTX (PSVT
Atrial Fibrillation) Adentri CV
Therapeutics Inc CVTX congestive
heart failure (CHF) Milnacipran Cypress
Biosciences CYPB fibromyalgia
syndrome (FMS) and related chronic pain
conditions SB-715992 Cytokinetics CYTK
multiple forms of cancer, including combination therapy
provenge Dendreon
DNDN
prostate cancer vaccine
APC8024(Neuvenge) Dendreon
DNDN HER-2/neu
positive cancers, including breast, ovarian
and colorectal cancers indiplon DOV
Pharmaceuticals DOVP insomnia
bicifadine DOV
Pharmaceuticals DOVP pain
ocinaplon DOV
Pharmaceuticals DOVP generalized
anxiety disorder DOV
216,303 DOV
Pharmaceuticals DOVP depression,
anxiety and substance abuse
DOV
Diltiazen DOV
Pharmaceuticals DOVP Angina
and Hypertension DX-88 Dyax DYAX hereditary
angioedema (HAE) DX-890 Dyax DYAX cystic
fibrosis (CF),chronic obstructive airways diseases
Thelin (sitaxsentan) Encysive
Pharmaceuticals ENCY pulmonary
arterial hypertension
(PAH)
BIMOSIAMOSE Encysive
Pharmaceuticals ENCY inhaled
therapy for asthma, psoriasis
and atopic dermatitis TBC3711 Encysive
Pharmaceuticals ENCY endothelin
A antagonis
Panzem
(2-methoxyestradiol) EntreMed ENMD cancer XL119 Exelixis EXEL bile
duct tumors Macugen(pegaptanib
sodium injection) Eyetech
Pharmaceuticals EYET wet
form of age-related macular degeneration (AMD) FM-VP4 Forbes
Medi-Tech FMTI
cholesterol-lowering
and anti-atherosclerotic
Genasense®
(oblimersen sodium Genta GNTA
melanoma, lung
and prostate cancers Ganite®
(gallium nitrate injection). Genta GNTA cancer
related hypercalcemia TNFerade GenVec
GNVC Tumor
necrosis factor alpha gene TVAX
Telomerase Cancer Vaccine (TVAX) Geron
GERN prostate
cancer Aquavan
Injection Guilford
Pharmaceuticals GLFD mild
to moderate sedation for non-invasive procedures
GPI
1485 Guilford
Pharmaceuticals GLFD Impotence,
Prostate Cancer GPI 5693
Guilford
Pharmaceuticals GLFD neuropathic
pain
MyVax Genitope
Corp GTOP idotypic
vaccine for cancer follicular non-Hodgkin's lymphoma
(f-NHL). ACAPODEME GTX
Inc. GTXI
Prevention of prostate
cancer in men with high grade PIN Andarine GTX
Inc. GTXI Cachexia
from various types of cancer
Ostarine GTX
Inc. GTXI andropause HE2100
NEUMUNE Hollis-Eden
Pharmaceuticals HEPH protecting
the body's bone marrow from acute radiation syndrom PHOSPHONOL Hollis-Eden
Pharmaceuticals HEPH protect
against DNA mutations (mutagenesis)-- from radiation (HE2000)
IMMUNITIN Hollis-Eden
Pharmaceuticals HEPH Malaria
and HIV and preclinical
benefit in a number of tuberculosis model
LymphoStat-B Human
Genome Sciences HGSI drugs
discovered through genomics-based research Albuferon Human
Genome Sciences HGSI hepatitis
C, b?? and a broad
range of cancers HGS-ETRI
Human
Genome Sciences HGSI apoptosis,
in cancer cells. HGS-TR2J Human
Genome Sciences HGSI apoptosis,
in cancer cells. 480848 Human
Genome Sciences HGSI inhibits
atherosclerotic plaques IC485 ICOS ICOS Chronic
Obstructive Pulmonary Disease Tadalafil
ICOS ICOS Benign
Prostatic Hyperplasia
FluINsure ID
Biomedical Corp IDBE vaccine
prevention of influenza (flu) StreptAvax ID
Biomedical Corp IDBE vaccine
for prevention of diseases caused by group A streptococcus
in children PPV
ID
Biomedical Corp IDBE vaccine
for the prevention of disease caused by Streptococcus
pneumoniae (pneumococcus) Pagocione Indevus
Pharmaceuticals IDEV Stuttering
PRO2000 Indevus
Pharmaceuticals IDEV HIV
and STD Prevention
IP
751 Indevus
Pharmaceuticals IDEV Pain
and Inflammation Aminocandin
Indevus
Pharmaceuticals IDEV Serious
Fungal Infections HuN901-DM1 Immunogen IMGN cancers
that express the CanAg antigen MLN2704 Immunogen IMGN -targets
the prostate-specific membrane antigen (PSMA) Cantuzumab
mertansine Immunogen IMGN cancers
that express the CanAg antigen Reverset
Incyte
Corp INCY
HIV CCR2
Antagonists Incyte
Corp INCY Rheumatoid
Arthritis, MS, Neuropathic Pain, Atherosclerosis
Sheddase
Inhibitors Incyte
Corp INCY Cancer ADVEXIN Introgen
Therapeutics INGN Cancer
?? Advexin (adenoviral p53) --bladder
cancer--gene therapy -PI INGN
241 Introgen
Therapeutics INGN tumor
suppressor product candidate INGN
225 Introgen
Therapeutics INGN tumor
vaccine Visicol
InKline
Pharamceuticals INKP Constipation
INKP-102
InKline
Pharamceuticals INKP Colon
cleansing prior to colonoscopy IB-Stat InKline
Pharamceuticals INKP Symptoms
associated with Irritable Bowel Syndrome (IBS) CEA-Scan
Immunomedics IMMU
targets tumors that have carcinoembryonic antigen (CEA) on their cell membrane
antisense
drugs ISIS
Pharmaceuticals ISIS
ulcerative colitis, diabetes, MS, cardiovascular disease, cancer, psoriasis diquafosol
tetrasodium (INS365 Ophthalmic) Inspire
Pharamceuticals ISPH for
the treatment of dry eye disease INS37217--
Respiratory (denufosol tetrasodium) Inspire
Pharamceuticals ISPH cystic
fibrosis, retinal disease IN50589 Inspire
Pharamceuticals ISPH Antiplatelet
for Platelet Inhibition Sulodexide
(KRX-101) Keryx
Biopharmaceuticals KERX diabetic
nephropathy Perifosine
(KRX-0401) Keryx
Biopharmaceuticals KERX multiple
forms of cancer KS
01-019 Kos
Pharmaceuticals KOSP dyslipidemia
KS
01-018 Kos
Pharmaceuticals KOSP Periperhal
Arterial Disease Azmacort Kos
Pharmaceuticals KOSP treatment
of asthma as prophylactic
therapy Targretin Ligand
Pharmaceuticals LGND non-small
cell lung cancer ONTAK
Ligand
Pharmaceuticals LGND B-
and T-cell non-Hodgkin's lymphomas
and chronic lymphocytic leukemia,
Targretin
gel Ligand
Pharmaceuticals LGND hand
dermatitis LJP 394 La
Jolla Pharmaceuticals LJPC Lupus
Erythematosus, Systemic Lupus Nephritis
Riquent®
(abetimus sodium La
Jolla Pharmaceuticals LJPC systemic
lupus erythematosus (SLE)
Ceplene Maxim
Pharmaceuticals MAXM Advanced
Melanoma, Acute Myeloid Leukemia, Renal Cell Carcinoma, Hepatitis C Medarex
Antibodies Medarex MEDX
cancer, inflammation,
autoimmune and infectious diseases Anidulafungin Vicuron
Pharmaceuticals MICU anti-fungal
Dalbavancin
Vicuron
Pharmaceuticals MICU glycopeptide
class of antibiotics (hospital infections) Oxazolidinones Vicuron
Pharmaceuticals MICU most-difficult-to-treat,
multi-drug-resistant bacteria Deformylase
Inhibitors Vicuron
Pharmaceuticals MICU antibiotic
-- respiratory tract infections INTEGRILIN®
(EPTIFIBATIDE) Millenium
Pharmaceuticals MLNM cardiovascular
VELCADE®
(bortezomib)- Millenium
Pharmaceuticals MLNM lung,
breast, prostate cancers
MLN1202,MLN2704 Millenium
Pharmaceuticals MLNM Rheumatoid
arthritis, multiple
sclerosis, inflammation
Technosphere
Insulin System MannKind
Corp MNKD pulmonary
delivery system for diabetes
Enoximone Myogen MYOG Advanced
Chronic Heart Failure
Ambristentan Myogen MYOG Pulmonary
Arterial Hypertension
Darusentan Myogen MYOG Uncontrolled
Hypertension Flurizan Myriad
Genetics Inc MYGN Alzheimer's,
cancer StaphVAX Nabi
Biopharmaceuticals NABI Vaccine
for staphylococcus
infections NicVax Nabi
Biopharmaceuticals NABI Vaccine
for smoking cessation vaccine Civacir
Nabi
Biopharmaceuticals NABI Hepatitis
C antibody-based therapies IL13-PE38QQR NeoPharm
Inc NEOL Glioblastoma
Multiforme brain tumor Liposomal
SN38 NeoPharm
Inc NEOL Advanced
cancers; including colorectal and lung Liposomal
c-raf Antisense Oligonucleotide NeoPharm
Inc NEOL Advanced
cancers; including pancreatic (monotherapy and combination with radiation/chemotherapy)
Liposomal
Paclitaxel-Easy-to-use NeoPharm
Inc NEOL Advanced
cancers; including breast cancer, lung and ovarian
Indiplon Neurocrine
Biosciences NBIX
insomnia via inhibitory
neurotransmitter
--- GABA
CRF Receptor
Antagonis Neurocrine
Biosciences NBIX Anxiety
and depression NBL- 5788 Neurocrine
Biosciences NBIX Multiple
Sclerosis Urocortin
2 Neurocrine
Biosciences NBIX Acute
congestive heart failure (CHF)
GnRH
antagonists Neurocrine
Biosciences NBIX Endometriosis PREOS®
(recombinant human parathyroid hormone) NPS
Pharmaceuticals NPSP
treatment of osteoporosis
Teduglutide NPS
Pharmaceuticals NPSP
gastrointestinal
disorders including Short Bowel Syndrome
Preotact NPS
Pharmaceuticals NPSP
Osteoperosis Calcilytics NPS
Pharmaceuticals NPSP
Osteoperosis
GlyT-1 NPS
Pharmaceuticals NPSP
Schizophrenia
Fibrillex Neurochem
Inc. NRMX AA
Amyloidosis Alzhemed Neurochem
Inc. NRMX Alzheimer's
Disease --inhibit the Amyloid
Cascade Cerebril Neurochem
Inc. NRMX Hemorrhagic
stroke due to cerebral amyloid
angiopathy Memantine
(Namenda) Neurobiological
Tech NTII progressive
neurological impairment due to neuronal injur
XERECEPT
-- natural human peptide CRF Neurobiological
Tech NTII
inhibitor of swelling, or edema
VIPRINEX™
(ancrod) Neurobiological
Tech NTII stroke
patients -- anticoagulation BiDil NitroMed
NTMD Heart
failure, or end-stage cardiovascular disease Alfimeprase Nuvelo NUVO thrombolytic
agent or blood clot dissolver rNAPc2 Nuvelo NUVO Factor
VIIa / Tissue Factor Inhibitor ARC183
Nuvelo
NUVO DNA-based
direct thrombin inhibitor-- anticoagulant
/ anti-thrombotic BAY
43-9006 Onyx
Pharmaceuticals ONXX advanced
renal (kidney) cancer Ramoplanin Oscient
Pharmaceuticals OSCI Clostridium
difficile-associated diarrhea
FACTIVE Oscient
Pharmaceuticals OSCI Intravenous--
Bacterial Infections CA4P
(combretastatin)-- Oxigene OXGN
Vascular targeting agent ??CK PHASE Motexafin
gadolinium Pharmacyclics
Inc. PCYC anti-cancer
product Motexafin
lutetium Pharmacyclics
Inc PCYC reduce
or eliminate “vulnerable plaque ” Apan Praecis
Pharmaceuticals PRCS Alzheimer's
Disease
PPI-2458 Praecis
Pharmaceuticals PRCS Non-Hodgkin's
Lymphoma/RA
MNTX Progenics
Pharmaceuticals PGNX Advanced
medical ilness, post-operative ileus, chronic pain GMX Progenics
Pharmaceuticals PGNX Melanoma
Cancer PSMA Progenics
Pharmaceuticals PGNX prostate
cancer
PRO542 Progenics
Pharmaceuticals PGNX HIV
PRO 140 Progenics
Pharmaceuticals PGNX HIV Trexima POZEN
Inc. POZN
migraine pain OXYTREX Pain
Therapeutics Inc. PTIE severe
chronic pain, such as low back,
osteoarthritic pain or cancer pain REMOXY Pain
Therapeutics Inc. PTIE proprietary
abuse-resistant version of time-release oxycodone PTI-901 Pain
Therapeutics Inc. PTIE chronic
Irritable Bowel Syndrome (IBS). AXOKINE
IL-1 REGN potential
treatment of obesity VEGF
Trap Regeneron
Pharmaceuticals REGN inihibits
tumor blood vessel growth
L-4/13
Trap Regeneron
Pharmaceuticals REGN treatment
in allergy and asthma
IL-1
Trap Regeneron
Pharmaceuticals REGN decreases
inflammation and blocks cartilage erosion in the joint -- Rhematoid Arthritis ZADAXIN Sciclone
Pharmaceuticals SCLN viral
infections-- hepatitis C,
and cancer SCV-07 Sciclone
Pharmaceuticals SCLN fight
infection SGN-30 Seattle
Genetics SGEN Hodgkin's
disease and some types of non-Hodgkin's lymphoma
SGN-15 Seattle
Genetics SGEN non-small
cell lung cancer
SGN-40 Seattle
Genetics SGEN multiple
myeloma and non-Hodgkin's lymphoma XIFAXAN™
(rifaximin) Salix
Pharmaceuticals SLXP gastrointestinal-
selective, oral antibiotic ZEGERID Santarus
Inc SNTS Heartburn/GERD,
Erosive esophagitis, Duodenal ulcers Orathecin Supergen
Inc. SUPG pancreatic
cancer Avicine™ Supergen
Inc. SUPG colorectal
cancer Satraplatin Spectrum
Pharmaceuticals SPPI
Prostate Cancer SPI-153 Spectrum
Pharmaceuticals SPPI Hormone
Depenmdent Prostate Cancer EOquin
Spectrum
Pharmaceuticals SPPI
Bladder Cancer, Radiation
Sensitizer
Elsamitrucin Spectrum
Pharmaceuticals SPPI
prosaptide Savient SVNT peripheral
neuropathic pain puricase Savient SVNT symptomatic
gout fibrimage Savient SVNT diagnostic
agent for the detection of deep vein
thrombosis I2S
Transkaryotic
Therapies TKTX Hunter
syndrome GA-GCB
Transkaryotic
Therapies TKTX Gaucher
disease TELCYTA
(TLK286) Telik
Inc. TELK advanced
ovarian cancer and
non-small cell lung cancer (a selective apoptotic agent)
TELINTRA Telik
Inc. TELK myelodysplastic
syndrome --Bone marrow stimulant TNX
-355 Tanox
Inc. TNOX HIV
T-1249 Trimeris
Inc. TRMS HIV Pivanex Titan
Pharmaceuticals TTP Refractory
Chronic Lymphocytic Leukemia DITPA Titan
Pharmaceuticals Congestive
Heart Failure Probuphine Titan
Pharmaceuticals Opiate
addition Spheramine Titan
Pharmaceuticals Advanced
Parkinson's
Iloperidone Titan
Pharmaceuticals Schizophrenia
Gallium
Maltolate Titan
Pharmaceuticals Bone
Disease
OvaRex United
Therapeutics Corp UTHR
Ovarian Cancer
Remodulin United
Therapeutics Corp UTHR Critical
limb ischemia (CLI) UT-231B United
Therapeutics Corp UTHR Hepatitis
C Celacade Vasogen
Inc. VSGN Chronic
Heart Failure, Periperheral Arterial Disease VP025 Vasogen
Inc. VSGN Alzheimer's
disease, Parkinson's
disease, and amyotrophic lateral sclerosis VX-385 Vertex
Pharmaceuticals VRTX HIV
infection Merimepodib
Vertex
Pharmaceuticals VRTX hepatitis
C VX-950 Vertex
Pharmaceuticals VRTX hepatitis
C VX-765 Vertex
Pharmaceuticals VRTX cytokine
inhibitor of interleukin-1 beta converting enzyme (ICE)
VX-702 Vertex
Pharmaceuticals VRTX acute
coronary syndromes Pralnacasan
Vertex
Pharmaceuticals VRTX
inflammatory diseases
VX944,
VX630 Vertex
Pharmaceuticals VRTX Cancer DNA Vaccines
Vical
Inc VICL malaria,
cytomegalovirus,
eboa, west nile virus, hiv,
hepatitis Avanafil Vivus
Inc. VVUS erectile
dysfunction ALISTA Vivus
Inc. VVUS female
sexual arousal disorder Testosterone
MDTS Vivus
Inc. VVUS low
sexual desire
Evamist Vivus
Inc. VVUS symptoms
associated with menopause Neuprex XOMA
LTD XOMA immunologic
and inflammatory disorders, cancer and infectious diseases
XMP.629 XOMA
LTD XOMA Acne
MLN2222 XOMA
LTD XOMA coronary
artery bypass graft (CABG) surgery patients. TransMID Xenova
Group XNVA Glioblastoma
multiforme (GBM) XR303 Xenova
Group XNVA Pancreatic
Cancer XR5944/XR11576 Xenova
Group XNVA Solid
Tumors TA-CD
Vaccine Xenova
Group XNVA Cocaine
addition
TA_NIC
Vaccine Xenova
Group XNVA Nicotine
Addiction Recombinant
human Thrombin Zymogenetics
Inc. ZGEN control
of bleeding associated with various surgical procedures
-TACI-Ig Zymogenetics
Inc. ZGEN autoimmune
diseases and for advanced B-cell malignancies
Interleukin
21 (IL-21) Zymogenetics
Inc. ZGEN cancer