Drugs at the Clinical Stage -- In the Pipeline

NEW Pipeline Drugs for Alzheimer's: Drugs for Alzheimer's Disease Pipeline Drugs for Schizophrenia: Drugs for Schizophrenia

The Biotech-100 Index includes 100 small cap biotechnology stocks whose product drug pipeline contain at least one drug in either phase II and/or Phase III clinical development. There is a 90% chance of rejection in early-stage phase I clinical trials; a 50% chance in phase II; 20% in phase III; and 10% post-phase III. Companies that are in phase II and III tend to show great promise but still have a high degree of volatiliy.

Pipeline Drugs	Company	Symbol	Application
ABX-EGF (panitumumab)	Abgenix	ABGX	targets the epidermal growth factor receptor (EGFr), which is over-expressed in a variety of cancers including lung cancer, breast cancer, bladder, pancreatic, colorectal cancer, kidney and head and neck cancer.
ABX-MA1	Abgenix	ABGX	ABX-MA1 targets a protein called MUC18, a cell-surface adhesion molecule that is highly expressed on metastatic melanoma cells but not on normal skin cells
ACP-103	Acadia	ACAD	Parkinson's Disease, adjunctive therapy for schizophrenia (Hallucinations, Psychoses)
Onconase (ranpirnase)	AlfaCell	ACEL	Ribonuclease anti-cancer drug,
Entereg (alvimopan)	Adolor	ADLR	pain management of POI and OBD
lidocaine patch	Adolor	ADLR	postoperative incisional pain
perifosine	Æterna Zentaris Inc	AEZS	Multiple myeloma and advanced metastatic colorectal cancer -- multiple cancers
SolorelTM (AEZS-130)	Æterna Zentaris Inc	AEZS	Growth hormone secretagogue-- potential applications for the treatment of cachexia
AEZS-108	Æterna Zentaris Inc	AEZS	Ovarian cancer, endometrial cancer
AG-858	Antigenics Inc.	AGEN	Chronic myelogenous leukemia (CML)
Oncophage	Antigenics Inc.	AGEN	Metastatic melanoma, Kidney cancer (renal cell carcinoma)
AG-702	Antigenics Inc.	AGEN	Genital herpes
V -Protectants® (AGI-1067)	Atherogenics	AGIX	chronic inflammatory diseases, such as atherosclerosis, rheumatoid arthritis and asthma
Vivitrex	Alkermes	ALKS	Alchol Dependence
Medisorb	Alkermes	ALKS	Diabetes
AIR Insulin	Alkermes	ALKS	Diabetes
AIR hGH	Alkermes	ALKS	GHD
AIR Epinephrine	Alkermes	ALKS	Anaphylaxis
Pexelizumab	Alexion	ALXN	Cardiopulmonary Bypass, Acute Myocardial Infarction
Eculizumab	Alexion	ALXN	Nephritis, Dermatomyositis , Paroxysmal Nocturnal Hemoglinuria
Efaproxiral	Allos Therapeutics	ALTH	Brain metastases from breast cancer, non-small cell lung cancer, cervical cancer
PDX (pralatrexate)	Allos Therapeutics	ALTH	non-small cell lung cancer, Mesothelioma, non-Hodgkin's Lymphoma
SYMLIN® (pramlintide acetate)	Amylin	AMLN	synthetic version of human amylin -glucose control with type 1 diabetes
exenatide (synthetic exendin-4)	Amylin	AMLN	type 2 diabetes
Isatoribine (ANA245)	Anadys	ANDS	Hepatitis C
ANA 380	Anadys	ANDS	Hepatitis B
Oral Prodrug ANA971	Anadys	ANDS	reduce the risk of HCV relapse
AMD3100	AnorMED	AOM.TO	stem cell mobilizer
AMD070	AnorMED	AOM.TO	chemokine inhibitor for HIV
Insegia(G17DT immunogen)	Aphton Corp	APHT	cancer and gastrointestinal disease
AP23573	Ariad	ARIA	solid tumor and blood malignancies
TP10	Avant	AVAN	Cardiac Surgery
CETi-I	Avant	AVAN	Cholesterol Management
CholeraGarde	Avant	AVAN	Cholera
Ty800	Avant	AVAN	Typhoid Fever
Injectable Anthrax	Avant	AVAN	Anthrax
Therapore	Avant	AVAN	HIV
Resten-NG	Avi Biopharma	AVII	cardiovascular restenosis
Avicine	Avi Biopharma	AVII	vaccine -- anti-hCG immune response targeting hCG-producing cancer cells
NeuGene compounds	Avi Biopharma	AVII	anti-sense drugs for cancer, polycystic kidney disease, and viral diseases
Neurodex	Avanir	AVN	pseudobulbar affect, neuropathic pain
Avanir	Avanir	AVN	Asthma
AV201	Avigin	AVGN	severe Parkinson's disease
Phenserine	Axonyx	AXYX	Alzheimer's disease
Theratope Vaccine	Biomira	BIOM	colorectal, metastatic breast cancer
BLP25 Liposome Vaccine	Biomira	BIOM	Prostate, non-small cell lung cancer
Modrenal	Bioenvision	BIVN	Prostate Cancer
Clofarabine (CLOLAR)	Bioenvision	BIVN	pediatric acute lymphoblastic leukemia, solid Tumors
Velostan	Bioenvision	BIVN	post-menopausal advanced breast cancer, bladder cancer
virostat	Bioenvision	BIVN	hepatitis C
GVAX (vaccine)	Cell Genesys	CEGE	Prostate, lung, pancreatic, leukemia, myeloma
CG7870 Oncolytic Virus Therapy	Cell Genesys	CEGE	Prostate cancer
Daptomycin (cubicin)	Cubist	CBST	soft tissue infection, infective endocarditis
HepeX-B	Cubist	CBST	prevention of infection by hepatitis B in liver transplant
Oracea	Collagenex Pharmaceuticals Inc	CGPI	rosacea
E2F Decoy	Corgentech	CGTK	Coronary Bypass Graft, Arterio-Venous Graft
mifepristone ( Corlux)	Corcept	CORT	Psychotic major depression, Alzheimers
Ventavis	CoTherix Inc	CTRX	pulmonary arterial hypertension
Ranexa	CV Therapeutics Inc	CVTX	Chronic Angina
Regadenoson	CV Therapeutics Inc	CVTX	Myocardial Perfusion Imaging
Tecadenoson	CV Therapeutics Inc	CVTX	(PSVT Atrial Fibrillation)
Adentri	CV Therapeutics Inc	CVTX	congestive heart failure (CHF)
Milnacipran	Cypress Biosciences	CYPB	fibromyalgia syndrome (FMS) and related chronic pain conditions
SB-715992	Cytokinetics	CYTK	multiple forms of cancer, including combination therapy
provenge	Dendreon	DNDN	prostate cancer vaccine
APC8024(Neuvenge)	Dendreon	DNDN	HER-2/neu positive cancers, including breast, ovarian and colorectal cancers
indiplon	DOV Pharmaceuticals	DOVP	insomnia
bicifadine	DOV Pharmaceuticals	DOVP	pain
ocinaplon	DOV Pharmaceuticals	DOVP	generalized anxiety disorder
DOV 216,303	DOV Pharmaceuticals	DOVP	depression, anxiety and substance abuse
DOV Diltiazen	DOV Pharmaceuticals	DOVP	Angina and Hypertension
DX-88	Dyax	DYAX	hereditary angioedema (HAE)
DX-890	Dyax	DYAX	cystic fibrosis (CF),chronic obstructive airways diseases
Thelin (sitaxsentan)	Encysive Pharmaceuticals	ENCY	pulmonary arterial hypertension (PAH)
BIMOSIAMOSE	Encysive Pharmaceuticals	ENCY	inhaled therapy for asthma, psoriasis and atopic dermatitis
TBC3711	Encysive Pharmaceuticals	ENCY	endothelin A antagonis
Panzem (2-methoxyestradiol)	EntreMed	ENMD	cancer
XL119	Exelixis	EXEL	bile duct tumors
Macugen(pegaptanib sodium injection)	Eyetech Pharmaceuticals	EYET	wet form of age-related macular degeneration (AMD)
FM-VP4	Forbes Medi-Tech	FMTI	cholesterol-lowering and anti-atherosclerotic
Genasense® (oblimersen sodium	Genta	GNTA	melanoma, lung and prostate cancers
Ganite® (gallium nitrate injection).	Genta	GNTA	cancer related hypercalcemia
TNFerade	GenVec	GNVC	Tumor necrosis factor alpha gene
TVAX Telomerase Cancer Vaccine (TVAX)	Geron	GERN	prostate cancer
Aquavan Injection	Guilford Pharmaceuticals	GLFD	mild to moderate sedation for non-invasive procedures
GPI 1485	Guilford Pharmaceuticals	GLFD	Impotence, Prostate Cancer
GPI 5693	Guilford Pharmaceuticals	GLFD	neuropathic pain
MyVax	Genitope Corp	GTOP	idotypic vaccine for cancer follicular non-Hodgkin's lymphoma (f-NHL).
ACAPODEME	GTX Inc.	GTXI	Prevention of prostate cancer in men with high grade PIN
Andarine	GTX Inc.	GTXI	Cachexia from various types of cancer
Ostarine	GTX Inc.	GTXI	andropause
HE2100 NEUMUNE	Hollis-Eden Pharmaceuticals	HEPH	protecting the body's bone marrow from acute radiation syndrom
PHOSPHONOL	Hollis-Eden Pharmaceuticals	HEPH	protect against DNA mutations (mutagenesis)-- from radiation
(HE2000) IMMUNITIN	Hollis-Eden Pharmaceuticals	HEPH	Malaria and HIV and preclinical benefit in a number of tuberculosis model
LymphoStat-B	Human Genome Sciences	HGSI	drugs discovered through genomics-based research
Albuferon	Human Genome Sciences	HGSI	hepatitis C, b?? and a broad range of cancers
HGS-ETRI	Human Genome Sciences	HGSI	apoptosis, in cancer cells.
HGS-TR2J	Human Genome Sciences	HGSI	apoptosis, in cancer cells.
480848	Human Genome Sciences	HGSI	inhibits atherosclerotic plaques
IC485	ICOS	ICOS	Chronic Obstructive Pulmonary Disease
Tadalafil	ICOS	ICOS	Benign Prostatic Hyperplasia
FluINsure	ID Biomedical Corp	IDBE	vaccine prevention of influenza (flu)
StreptAvax	ID Biomedical Corp	IDBE	vaccine for prevention of diseases caused by group A streptococcus in children
PPV	ID Biomedical Corp	IDBE	vaccine for the prevention of disease caused by Streptococcus pneumoniae (pneumococcus)
Pagocione	Indevus Pharmaceuticals	IDEV	Stuttering
PRO2000	Indevus Pharmaceuticals	IDEV	HIV and STD Prevention
IP 751	Indevus Pharmaceuticals	IDEV	Pain and Inflammation
Aminocandin	Indevus Pharmaceuticals	IDEV	Serious Fungal Infections
HuN901-DM1	Immunogen	IMGN	cancers that express the CanAg antigen
MLN2704	Immunogen	IMGN	-targets the prostate-specific membrane antigen (PSMA)
Cantuzumab mertansine	Immunogen	IMGN	cancers that express the CanAg antigen
Reverset	Incyte Corp	INCY	HIV
CCR2 Antagonists	Incyte Corp	INCY	Rheumatoid Arthritis, MS, Neuropathic Pain, Atherosclerosis
Sheddase Inhibitors	Incyte Corp	INCY	Cancer
ADVEXIN	Introgen Therapeutics	INGN	Cancer ?? Advexin (adenoviral p53) --bladder cancer--gene therapy -PI
INGN 241	Introgen Therapeutics	INGN	tumor suppressor product candidate
INGN 225	Introgen Therapeutics	INGN	tumor vaccine
Visicol	InKline Pharamceuticals	INKP	Constipation
INKP-102	InKline Pharamceuticals	INKP	Colon cleansing prior to colonoscopy
IB-Stat	InKline Pharamceuticals	INKP	Symptoms associated with Irritable Bowel Syndrome (IBS)
CEA-Scan	Immunomedics	IMMU	targets tumors that have carcinoembryonic antigen (CEA) on their cell membrane
antisense drugs	ISIS Pharmaceuticals	ISIS	ulcerative colitis, diabetes, MS, cardiovascular disease, cancer, psoriasis
diquafosol tetrasodium (INS365 Ophthalmic)	Inspire Pharamceuticals	ISPH	for the treatment of dry eye disease
INS37217-- Respiratory (denufosol tetrasodium)	Inspire Pharamceuticals	ISPH	cystic fibrosis, retinal disease
IN50589	Inspire Pharamceuticals	ISPH	Antiplatelet for Platelet Inhibition
Sulodexide (KRX-101)	Keryx Biopharmaceuticals	KERX	diabetic nephropathy
Perifosine (KRX-0401)	Keryx Biopharmaceuticals	KERX	multiple forms of cancer
KS 01-019	Kos Pharmaceuticals	KOSP	dyslipidemia
KS 01-018	Kos Pharmaceuticals	KOSP	Periperhal Arterial Disease
Azmacort	Kos Pharmaceuticals	KOSP	treatment of asthma as prophylactic therapy
Targretin	Ligand Pharmaceuticals	LGND	non-small cell lung cancer
ONTAK	Ligand Pharmaceuticals	LGND	B- and T-cell non-Hodgkin's lymphomas and chronic lymphocytic leukemia,
Targretin gel	Ligand Pharmaceuticals	LGND	hand dermatitis
LJP 394	La Jolla Pharmaceuticals	LJPC	Lupus Erythematosus, Systemic Lupus Nephritis
Riquent® (abetimus sodium	La Jolla Pharmaceuticals	LJPC	systemic lupus erythematosus (SLE)
Ceplene	Maxim Pharmaceuticals	MAXM	Advanced Melanoma, Acute Myeloid Leukemia, Renal Cell Carcinoma, Hepatitis C
Medarex Antibodies	Medarex	MEDX	cancer, inflammation, autoimmune and infectious diseases
Anidulafungin	Vicuron Pharmaceuticals	MICU	anti-fungal
Dalbavancin	Vicuron Pharmaceuticals	MICU	glycopeptide class of antibiotics (hospital infections)
Oxazolidinones	Vicuron Pharmaceuticals	MICU	most-difficult-to-treat, multi-drug-resistant bacteria
Deformylase Inhibitors	Vicuron Pharmaceuticals	MICU	antibiotic -- respiratory tract infections
INTEGRILIN® (EPTIFIBATIDE)	Millenium Pharmaceuticals	MLNM	cardiovascular
VELCADE® (bortezomib)-	Millenium Pharmaceuticals	MLNM	lung, breast, prostate cancers
MLN1202,MLN2704	Millenium Pharmaceuticals	MLNM	Rheumatoid arthritis, multiple sclerosis, inflammation
Technosphere Insulin System	MannKind Corp	MNKD	pulmonary delivery system for diabetes
Enoximone	Myogen	MYOG	Advanced Chronic Heart Failure
Ambristentan	Myogen	MYOG	Pulmonary Arterial Hypertension
Darusentan	Myogen	MYOG	Uncontrolled Hypertension
Flurizan	Myriad Genetics Inc	MYGN	Alzheimer's, cancer
StaphVAX	Nabi Biopharmaceuticals	NABI	Vaccine for staphylococcus infections
NicVax	Nabi Biopharmaceuticals	NABI	Vaccine for smoking cessation vaccine
Civacir	Nabi Biopharmaceuticals	NABI	Hepatitis C antibody-based therapies
IL13-PE38QQR	NeoPharm Inc	NEOL	Glioblastoma Multiforme brain tumor
Liposomal SN38	NeoPharm Inc	NEOL	Advanced cancers; including colorectal and lung
Liposomal c-raf Antisense Oligonucleotide	NeoPharm Inc	NEOL	Advanced cancers; including pancreatic (monotherapy and combination with radiation/chemotherapy)
Liposomal Paclitaxel-Easy-to-use	NeoPharm Inc	NEOL	Advanced cancers; including breast cancer, lung and ovarian
Indiplon	Neurocrine Biosciences	NBIX	insomnia via inhibitory neurotransmitter --- GABA
CRF Receptor Antagonis	Neurocrine Biosciences	NBIX	Anxiety and depression
NBL- 5788	Neurocrine Biosciences	NBIX	Multiple Sclerosis
Urocortin 2	Neurocrine Biosciences	NBIX	Acute congestive heart failure (CHF)
GnRH antagonists	Neurocrine Biosciences	NBIX	Endometriosis
PREOS® (recombinant human parathyroid hormone)	NPS Pharmaceuticals	NPSP	treatment of osteoporosis
Teduglutide	NPS Pharmaceuticals	NPSP	gastrointestinal disorders including Short Bowel Syndrome
Preotact	NPS Pharmaceuticals	NPSP	Osteoperosis
Calcilytics	NPS Pharmaceuticals	NPSP	Osteoperosis
GlyT-1	NPS Pharmaceuticals	NPSP	Schizophrenia
Fibrillex	Neurochem Inc.	NRMX	AA Amyloidosis
Alzhemed	Neurochem Inc.	NRMX	Alzheimer's Disease --inhibit the Amyloid Cascade
Cerebril	Neurochem Inc.	NRMX	Hemorrhagic stroke due to cerebral amyloid angiopathy
Memantine (Namenda)	Neurobiological Tech	NTII	progressive neurological impairment due to neuronal injur
XERECEPT -- natural human peptide CRF	Neurobiological Tech	NTII	inhibitor of swelling, or edema
VIPRINEX™ (ancrod)	Neurobiological Tech	NTII	stroke patients -- anticoagulation
BiDil	NitroMed	NTMD	Heart failure, or end-stage cardiovascular disease
Alfimeprase	Nuvelo	NUVO	thrombolytic agent or blood clot dissolver
rNAPc2	Nuvelo	NUVO	Factor VIIa / Tissue Factor Inhibitor
ARC183	Nuvelo	NUVO	DNA-based direct thrombin inhibitor-- anticoagulant / anti-thrombotic
BAY 43-9006	Onyx Pharmaceuticals	ONXX	advanced renal (kidney) cancer
Ramoplanin	Oscient Pharmaceuticals	OSCI	Clostridium difficile-associated diarrhea
FACTIVE	Oscient Pharmaceuticals	OSCI	Intravenous-- Bacterial Infections
CA4P (combretastatin)--	Oxigene	OXGN	Vascular targeting agent ??CK PHASE
Motexafin gadolinium	Pharmacyclics Inc.	PCYC	anti-cancer product
Motexafin lutetium	Pharmacyclics Inc	PCYC	reduce or eliminate “vulnerable plaque ”
Apan	Praecis Pharmaceuticals	PRCS	Alzheimer's Disease
PPI-2458	Praecis Pharmaceuticals	PRCS	Non-Hodgkin's Lymphoma/RA
MNTX	Progenics Pharmaceuticals	PGNX	Advanced medical ilness, post-operative ileus, chronic pain
GMX	Progenics Pharmaceuticals	PGNX	Melanoma Cancer
PSMA	Progenics Pharmaceuticals	PGNX	prostate cancer
PRO542	Progenics Pharmaceuticals	PGNX	HIV
PRO 140	Progenics Pharmaceuticals	PGNX	HIV
Trexima	POZEN Inc.	POZN	migraine pain
OXYTREX	Pain Therapeutics Inc.	PTIE	severe chronic pain, such as low back, osteoarthritic pain or cancer pain
REMOXY	Pain Therapeutics Inc.	PTIE	proprietary abuse-resistant version of time-release oxycodone
PTI-901	Pain Therapeutics Inc.	PTIE	chronic Irritable Bowel Syndrome (IBS).
AXOKINE IL-1	Regeneron Pharmaceuticals	REGN	potential treatment of obesity
VEGF Trap	Regeneron Pharmaceuticals	REGN	inihibits tumor blood vessel growth
L-4/13 Trap	Regeneron Pharmaceuticals	REGN	treatment in allergy and asthma
IL-1 Trap	Regeneron Pharmaceuticals	REGN	decreases inflammation and blocks cartilage erosion in the joint -- Rhematoid Arthritis
ZADAXIN	Sciclone Pharmaceuticals	SCLN	viral infections-- hepatitis C, and cancer
SCV-07	Sciclone Pharmaceuticals	SCLN	fight infection
SGN-30	Seattle Genetics	SGEN	Hodgkin's disease and some types of non-Hodgkin's lymphoma
SGN-15	Seattle Genetics	SGEN	non-small cell lung cancer
SGN-40	Seattle Genetics	SGEN	multiple myeloma and non-Hodgkin's lymphoma
XIFAXAN™ (rifaximin)	Salix Pharmaceuticals	SLXP	gastrointestinal- selective, oral antibiotic
ZEGERID	Santarus Inc	SNTS	Heartburn/GERD, Erosive esophagitis, Duodenal ulcers
Orathecin	Supergen Inc.	SUPG	pancreatic cancer
Avicine™	Supergen Inc.	SUPG	colorectal cancer
Satraplatin	Spectrum Pharmaceuticals	SPPI	Prostate Cancer
SPI-153	Spectrum Pharmaceuticals	SPPI	Hormone Depenmdent Prostate Cancer
EOquin	Spectrum Pharmaceuticals	SPPI	Bladder Cancer, Radiation Sensitizer
Elsamitrucin	Spectrum Pharmaceuticals	SPPI	Non-Hodgkin's Lymphoma
prosaptide	Savient	SVNT	peripheral neuropathic pain
puricase	Savient	SVNT	symptomatic gout
fibrimage	Savient	SVNT	diagnostic agent for the detection of deep vein thrombosis
I2S	Transkaryotic Therapies	TKTX	Hunter syndrome
GA-GCB	Transkaryotic Therapies	TKTX	Gaucher disease
TELCYTA (TLK286)	Telik Inc.	TELK	advanced ovarian cancer and non-small cell lung cancer (a selective apoptotic agent)
TELINTRA	Telik Inc.	TELK	myelodysplastic syndrome --Bone marrow stimulant
TNX -355	Tanox Inc.	TNOX	HIV
T-1249	Trimeris Inc.	TRMS	HIV
Pivanex	Titan Pharmaceuticals	TTP	Refractory Chronic Lymphocytic Leukemia
DITPA	Titan Pharmaceuticals		Congestive Heart Failure
Probuphine	Titan Pharmaceuticals		Opiate addition
Spheramine	Titan Pharmaceuticals		Advanced Parkinson's
Iloperidone	Titan Pharmaceuticals		Schizophrenia
Gallium Maltolate	Titan Pharmaceuticals		Bone Disease
OvaRex	United Therapeutics Corp	UTHR	Ovarian Cancer
Remodulin	United Therapeutics Corp	UTHR	Critical limb ischemia (CLI)
UT-231B	United Therapeutics Corp	UTHR	Hepatitis C
Celacade	Vasogen Inc.	VSGN	Chronic Heart Failure, Periperheral Arterial Disease
VP025	Vasogen Inc.	VSGN	Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis
VX-385	Vertex Pharmaceuticals	VRTX	HIV infection
Merimepodib	Vertex Pharmaceuticals	VRTX	hepatitis C
VX-950	Vertex Pharmaceuticals	VRTX	hepatitis C
VX-765	Vertex Pharmaceuticals	VRTX	cytokine inhibitor of interleukin-1 beta converting enzyme (ICE)
VX-702	Vertex Pharmaceuticals	VRTX	acute coronary syndromes
Pralnacasan	Vertex Pharmaceuticals	VRTX	inflammatory diseases
VX944, VX630	Vertex Pharmaceuticals	VRTX	Cancer
DNA Vaccines	Vical Inc	VICL	malaria, cytomegalovirus, eboa, west nile virus, hiv, hepatitis
Avanafil	Vivus Inc.	VVUS	erectile dysfunction
ALISTA	Vivus Inc.	VVUS	female sexual arousal disorder
Testosterone MDTS	Vivus Inc.	VVUS	low sexual desire
Evamist	Vivus Inc.	VVUS	symptoms associated with menopause
Neuprex	XOMA LTD	XOMA	immunologic and inflammatory disorders, cancer and infectious diseases
XMP.629	XOMA LTD	XOMA	Acne
MLN2222	XOMA LTD	XOMA	coronary artery bypass graft (CABG) surgery patients.
TransMID	Xenova Group	XNVA	Glioblastoma multiforme (GBM)
XR303	Xenova Group	XNVA	Pancreatic Cancer
XR5944/XR11576	Xenova Group	XNVA	Solid Tumors
TA-CD Vaccine	Xenova Group	XNVA	Cocaine addition
TA_NIC Vaccine	Xenova Group	XNVA	Nicotine Addiction
Recombinant human Thrombin	Zymogenetics Inc.	ZGEN	control of bleeding associated with various surgical procedures
-TACI-Ig	Zymogenetics Inc.	ZGEN	autoimmune diseases and for advanced B-cell malignancies
Interleukin 21 (IL-21)	Zymogenetics Inc.	ZGEN	cancer